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dc.contributor.authorVelasco-Alzate, Karen Y.-
dc.contributor.authorBauermeister, Anelize-
dc.contributor.authorTangerina, Marcelo M. P.-
dc.contributor.authorLotufo, Tito Monteiro da Cruz-
dc.contributor.authorFerreira, Marcelo J. P.-
dc.contributor.authorJimenez, Paula C.-
dc.contributor.authorPadilla, Gabriel-
dc.contributor.authorLopes, Norberto Peporine-
dc.contributor.authorCosta-Lotufo, Letícia V.-
dc.date.accessioned2023-09-11T13:29:04Z-
dc.date.available2023-09-11T13:29:04Z-
dc.date.issued2019-
dc.identifier.citationALZATE-VELASCO, K. ; BAUERMEISTER, A. ; TANGERINA, M. ; LOTUFO, Tito Monteiro da Cruz; FERREIRA, Marcelo J. P.; JIMENEZ, Paula Christine ; PADILLA, Gabriel ; Lopes, Norberto Peporine ; COSTA-LOTUFO, Letícia V. Marine bacteria from rocas atoll: a promising biotechnological resource. Marine Drugs, Switzerland, v. 17, p. 671, 2019. Disponível em: https://www.mdpi.com/1660-3397/17/12/671.Acesso em: 11 set. 2023.pt_BR
dc.identifier.issn1660-3397-
dc.identifier.urihttp://repositorio.ufc.br/handle/riufc/74263-
dc.description.abstractRocas Atoll is a unique environment in the equatorial Atlantic Ocean, hosting a large number of endemic species, however, studies on the chemical diversity emerging from this biota are rather scarce. Therefore, the present work aims to assess the metabolomic diversity and pharmacological potential of the microbiota from Rocas Atoll. A total of 76 bacteria were isolated and cultured in liquid culture media to obtain crude extracts. About one third (34%) of these extracts were recognized as cytotoxic against human colon adenocarcinoma HCT-116 cell line. 16S rRNA gene sequencing analyses revealed that the bacteria producing cytotoxic extracts were mainly from the Actinobacteria phylum, including Streptomyces, Salinispora, Nocardiopsis, and Brevibacterium genera, and in a smaller proportion from Firmicutes phylum (Bacillus). The search in the spectral library in GNPS (Global Natural Products Social Molecular Networking) unveiled a high chemodiversity being produced by these bacteria, including rifamycins, antimycins, desferrioxamines, ferrioxamines, surfactins, surugamides, staurosporines, and saliniketals, along with several unidentified compounds. Using an original approach, molecular networking successfully highlighted groups of compounds responsible for the cytotoxicity of crude extracts. Application of DEREPLICATOR+ (GNPS) allowed the annotation of macrolide novonestimycin derivatives as the cytotoxic compounds existing in the extracts produced by Streptomyces BRB-298 and BRB-302. Overall, these results highlighted the pharmacological potential of bacteria from this singular atoll.pt_BR
dc.language.isoenpt_BR
dc.publisherMarine Drugspt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMarine bacteria from rocas atoll: a promising biotechnological resourcept_BR
dc.typeArtigo de Periódicopt_BR
dc.subject.ptbrRochaspt_BR
dc.subject.ptbrDiversidade microbiologicapt_BR
dc.subject.ptbrBactéria Marinhapt_BR
dc.subject.enRocas Atollpt_BR
dc.subject.enMicrobial diversitypt_BR
dc.subject.enMarine bacteriapt_BR
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