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http://repositorio.ufc.br/handle/riufc/71367| Type: | Artigo de Periódico |
| Title: | Anthracyclinones from Micromonospora sp. |
| Authors: | Sousa, Thiciana da S. Jimenez, Paula C. Ferreira, Elthon G. Silveira, Edilberto R. Braz-Filho, Raimundo Pessoa, Otília D. L. Costa-Lotufo, Letícia Veras |
| Keywords: | Anthracyclinones;Chemical compounds;Citotoxity;Antracilinas;Compostos químicos;Cito-toxicidade |
| Issue Date: | 2012 |
| Publisher: | Journal of Natural Products |
| Citation: | SOUSA, Thiciana da S.; JIMENEZ, Paula C.;FERREIRA, Elthon G.; SILVEIRA, Edilberto R.; BRAZ FILHO, Raimundo; PESSOA, Otília D. L; COSTA-LOTUFO, Letícia Veras. Anthracyclinones from Micromonospora sp. Journal of Natural Products,United States, v. 75, p. 489-493, 2012. . Disponível em: https://pubs.acs.org/doi/pdf/10.1021/np200795p. Acesso em: 21 mar. 2023. |
| Abstract: | Four new anthracyclinones, 4,6,11-trihydroxy9-propyltetracene-5,12-dione (1), 1-methoxy-9-propyltetracene-6,11-dione (2), 7,8,9,10-tetrahydro-9-hydroxy-1-methoxy9-propyltetracene-6,11-dione (3), and 10β-carbomethoxy-7, 8,9,10-tetrahydro-4,6,7α,9α,11-pentahydroxy-9-propyltetracene-5,12-dione (4), were isolated from a strain of Micromonospora sp. associated with the tunicate Eudistoma vannamei. All structures were established by 1D and 2D NMR (COSY, HSQC, HMBC, NOESY) and HRESIMS experiments. Compounds 1 and 4 were cytotoxic against the HCT-8 human colon adenocarcinoma cell line, with IC50 values of 12.7 and 6.2 μM, respectively, while compounds 2 and 3 were inactive. |
| URI: | http://www.repositorio.ufc.br/handle/riufc/71367 |
| ISSN: | 1539-8854 |
| Appears in Collections: | LABOMAR - Artigos publicados em revistas científicas |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2012_art_tssousa.pdf | 1,22 MB | Adobe PDF | View/Open |
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