Anthracyclinones from Micromonospora sp.

Sousa, Thiciana da S.; Jimenez, Paula C.; Ferreira, Elthon G.; Silveira, Edilberto R.; Braz-Filho, Raimundo; Pessoa, Otília D. L.; Costa-Lotufo, Letícia Veras

Please use this identifier to cite or link to this item: http://repositorio.ufc.br/handle/riufc/71367

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DC Field	Value	Language
dc.contributor.author	Sousa, Thiciana da S.	-
dc.contributor.author	Jimenez, Paula C.	-
dc.contributor.author	Ferreira, Elthon G.	-
dc.contributor.author	Silveira, Edilberto R.	-
dc.contributor.author	Braz-Filho, Raimundo	-
dc.contributor.author	Pessoa, Otília D. L.	-
dc.contributor.author	Costa-Lotufo, Letícia Veras	-
dc.date.accessioned	2023-03-21T16:29:35Z	-
dc.date.available	2023-03-21T16:29:35Z	-
dc.date.issued	2012	-
dc.identifier.citation	SOUSA, Thiciana da S.; JIMENEZ, Paula C.;FERREIRA, Elthon G.; SILVEIRA, Edilberto R.; BRAZ FILHO, Raimundo; PESSOA, Otília D. L; COSTA-LOTUFO, Letícia Veras. Anthracyclinones from Micromonospora sp. Journal of Natural Products,United States, v. 75, p. 489-493, 2012. . Disponível em: https://pubs.acs.org/doi/pdf/10.1021/np200795p. Acesso em: 21 mar. 2023.	pt_BR
dc.identifier.issn	1539-8854	-
dc.identifier.uri	http://www.repositorio.ufc.br/handle/riufc/71367	-
dc.description.abstract	Four new anthracyclinones, 4,6,11-trihydroxy9-propyltetracene-5,12-dione (1), 1-methoxy-9-propyltetracene-6,11-dione (2), 7,8,9,10-tetrahydro-9-hydroxy-1-methoxy9-propyltetracene-6,11-dione (3), and 10β-carbomethoxy-7, 8,9,10-tetrahydro-4,6,7α,9α,11-pentahydroxy-9-propyltetracene-5,12-dione (4), were isolated from a strain of Micromonospora sp. associated with the tunicate Eudistoma vannamei. All structures were established by 1D and 2D NMR (COSY, HSQC, HMBC, NOESY) and HRESIMS experiments. Compounds 1 and 4 were cytotoxic against the HCT-8 human colon adenocarcinoma cell line, with IC50 values of 12.7 and 6.2 μM, respectively, while compounds 2 and 3 were inactive.	pt_BR
dc.language.iso	en	pt_BR
dc.publisher	Journal of Natural Products	pt_BR
dc.subject	Anthracyclinones	pt_BR
dc.subject	Chemical compounds	pt_BR
dc.subject	Citotoxity	pt_BR
dc.subject	Antracilinas	pt_BR
dc.subject	Compostos químicos	pt_BR
dc.subject	Cito-toxicidade	pt_BR
dc.title	Anthracyclinones from Micromonospora sp.	pt_BR
dc.type	Artigo de Periódico	pt_BR
Appears in Collections:	LABOMAR - Artigos publicados em revistas científicas

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