Please use this identifier to cite or link to this item: http://repositorio.ufc.br/handle/riufc/64064
Type: Artigo de Periódico
Title: Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission
Authors: Magalhães, Herbert S.
Silva, Alison B.da
Nascimento, Nilberto Robson Falcão do
Sousa, Luis Gustavo F. de
Fonseca, Maria Júlia S. da
Loiola, Maria Iracema B.
Monteiro, Norberto K. V.
Almeida Neto, Francisco Wagner de Queiroz
Canuto, Kirley Marques
Pessoa, Otilia Deusdênia L.
Keywords: Rauvolfia ligustrina;Indole alkaloids;Neuroinhibitory effect;GIAO 13C NMR
Issue Date: 2020
Publisher: Fitoterapia
Citation: MAGALHÃES, Herbert S. et al. Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission. Fitoterapia, [s. l.], v. 143, p. 1-7, 2020.
Abstract in Brazilian Portuguese: The new glucosyl sarpagan alkaloid designated as 21(R*)-(O-β-glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a soluble alkaloidal fraction from the ethanol extract of Rauvolfia ligustrina. Their structures were elucidated by interpretation of spectroscopic data (1D and 2D NMR), HRESIMS experiment, GIAO 13C NMR calculations, and comparison with literature data. All the isolated alka- loids were screened by their neuroinhibitory effects using the electrically stimulated mice vas deferens bioassay. Compounds 1, 2 and 9 presented a potent inhibitory effect in the neurotransmission while 3 and 11 showed an acute neuroexcitatory effect. Compound 10 exhibited a very effective post-synaptic inhibitory activity
URI: http://www.repositorio.ufc.br/handle/riufc/64064
Access Rights: Acesso Aberto
Appears in Collections:DBIO - Artigos publicados em revista científica

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