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dc.contributor.authorMagalhães, Herbert S.-
dc.contributor.authorSilva, Alison B.da-
dc.contributor.authorNascimento, Nilberto Robson Falcão do-
dc.contributor.authorSousa, Luis Gustavo F. de-
dc.contributor.authorFonseca, Maria Júlia S. da-
dc.contributor.authorLoiola, Maria Iracema B.-
dc.contributor.authorMonteiro, Norberto K. V.-
dc.contributor.authorAlmeida Neto, Francisco Wagner de Queiroz-
dc.contributor.authorCanuto, Kirley Marques-
dc.contributor.authorPessoa, Otilia Deusdênia L.-
dc.date.accessioned2022-02-18T18:32:46Z-
dc.date.available2022-02-18T18:32:46Z-
dc.date.issued2020-
dc.identifier.citationMAGALHÃES, Herbert S. et al. Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission. Fitoterapia, [s. l.], v. 143, p. 1-7, 2020.pt_BR
dc.identifier.urihttp://www.repositorio.ufc.br/handle/riufc/64064-
dc.language.isopt_BRpt_BR
dc.publisherFitoterapiapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectRauvolfia ligustrinapt_BR
dc.subjectIndole alkaloidspt_BR
dc.subjectNeuroinhibitory effectpt_BR
dc.subjectGIAO 13C NMRpt_BR
dc.titleEffect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmissionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.description.abstract-ptbrThe new glucosyl sarpagan alkaloid designated as 21(R*)-(O-β-glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a soluble alkaloidal fraction from the ethanol extract of Rauvolfia ligustrina. Their structures were elucidated by interpretation of spectroscopic data (1D and 2D NMR), HRESIMS experiment, GIAO 13C NMR calculations, and comparison with literature data. All the isolated alka- loids were screened by their neuroinhibitory effects using the electrically stimulated mice vas deferens bioassay. Compounds 1, 2 and 9 presented a potent inhibitory effect in the neurotransmission while 3 and 11 showed an acute neuroexcitatory effect. Compound 10 exhibited a very effective post-synaptic inhibitory activitypt_BR
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