Estudo químico e farmacológico de Senna georgica H. S Irwin & Barneby

Abstract

The known metabolites of the genus Senna have a variety of applications, while the oldest is like purging and preparation is present in the British Pharmacopoeia, European, American and Brazilian indicated for cases of constipation. Are used in folk medicine preparations of various species of the genus as, stomachic, febrifuge, antianemics, antiblenorrágica, antinefrítica,antidot a, antimycotic, diuretic, fungicidal, laxative and against skin diseases. In this stdy is described the investigation of chemical of Senna georgica H. S. Irwin Barneby (Leguminoseae), popularly known as "Lava prato” and "mata pasto". The literature review revealed the complete absence of studies chemical, biological and pharmacological performed with this species, which is why the plant was selected for the study. The chemical study started with chromatographic treatment of hexane andethanol extracts of Senna which allowed the isolation and identification of two anthraquinones crisofanol and fisciona,the triterpene lupeol, two phytosteroid shaped and acid free and glycosylated triacontanóico. Another stage of the work was devoted to the pharmacological study of S.georgica, which analyzed by testing the antioxidant potential, cytotoxicity and anticolinasterásico of extracts hexane and ethanol of flowers, pods, leaves, stem and root of the plant. The structural determinations were made using techniques of infrared spectroscopy, nuclear magnetic resonance of a 1-H-and C-13 uni-dimensional, mass spectrometry and comparison with data reported in the literature.