Avaliação neurocognitiva de pessoas vivendo com HIV/AIDS em Fortaleza-CE

Abstract

Chronic central nervous system (CNS) infection with HIV may be associated with HIV- associated neurocognitive disorder (HAND). This disorder has become more evident

and concerning with the aging of the population living with HIV (PLHIV), as it has the potential to have an adverse functional impact, with impairment of various cognitive functions. The clinical diagnosis of HAND is based on various neuropsychological and functional tests. However, in many cases, the application of these tests may be impractical. The International HIV Dementia Scale (IHDS) is a simple, rapid, and validated screening test for the Brazilian population that can detect all forms of HAND. A cross-sectional study was conducted to estimate the frequency of HAND using the IHDS in conjunction with the Lawton Scale. Sixty-one patients were evaluated, with a prevalence of 63.93% of all forms of HAND and a correlation between this disorder and education (ρ = 0.656; p < 0.001), CD4 nadir (r = 0.28; p = 0.03), CD4 cell count (r = 0.29; p = 0.023), CD4/CD8 ratio (r = 0.552; p < 0.001), PHQ-9 (r = -0.446; p <0.001), GAD-7 (r = -0.354; p = 0.003), age (r = -0.761; p <0.001) and treatment time (r = -0.35; p = 0.006). After multivariate analysis, those with advanced age, lower education level and lower CD4/CD8 ratio independently presented worse IHDS values, showing themselves to be more susceptible to HAND and, therefore, should be screened for this condition.