Perfil de notificação em farmacovigilância de um hospital sentinela em Fortaleza–CE

Abstract

The aims of this work were study and identify the profile of reports on drug adverse effects in a Sentinel Hospital of Fortaleza-CE, to assess the main events , most frequent adverse effect type, drugs most involved as well as susceptible patients characteristics in order to assist the clinical routines of professionals within the institution, serving as a working tool and knowledge promoter assisting identification, treatment, prevention and remedy the occurrence of drug related adverse effects. Thus were analyzed the spontaneous notification formularies that were referred to the University’s Hospital Walter Cantídio risk managing in the period from January 2011 to December 2012, which assessed the total number of notifications, the drugs were classified according to the 1 level ATC (Anatomical Therapeutic Chemical) and the reactions were classified using the Adverse Reaction Terminology (ART). In the period between 2011 and 2012 were collected 173 reporting forms, with 63 cards in 2011 and 110 chips in 2012. The months with the highest expression were May, August and October. Females were more affected (n = 93, 53.76%) than men (n = 80, 46.24%), the most frequent age group was to Adults (n = 118, 68.20%), followed by age Elderly (n = 28, 16.18%). The Spontaneous was the highest number (n = 156, 90.17%), with the pharmacist being the most professional reporter (n = 101, 58.38%), followed by the professional nurse (n = 33; 19.08 %). The sectors most occurrences of ADR reporting were chemotherapy (n = 56, 32.37%), hematology (n = 27, 15.61%), transplantation (n = 25, 14.45%) and ICU (n = 21; 12.14%). Drug group was involved more antineoplastic agents and immunosuppressants (n = 98; 44.14%). The skin disorders and skin disorders were the most frequent reactions (n = 120, 40.82%). Thus, it was observed relative importance of chemotherapy drugs and antibiotics involved in adverse reactions, as well as most of the patients involved were adults, with significant participation of pharmacists in reports of suspected adverse drug reaction.