Avaliação comportamental do tipo depressivo em camundongos C57BL/6 submetidos ao uso prolongado de Omeprazol

Abstract

Depressive Disorder is one of the most prevalent mental disorders, which impairs the functional capability to execute social activities. It is characterized by chronic sadness, reduction of interest in pleasure activities (anhedonia), irritability and cognitive dysfunction. Researchers suggest the use of drugs belonged to Proton Pump Inhibitor (IBP) class, mainly over chronic use, is associated to effects at Central Nervous System (CNS) level, like Depression. Therefore, the objective of the current research was investigating the relationship between the chronic administration of Omeprazole (OME), a drug belonged to IBP class, with depressive-like behavior in animals. To this end, C57BL/6 adult mice, weighting 20-30 g, were divided into two groups: OME and Control, which received orraly an Omeprazole suspension (8 mg/kg) and a vehicle solution (8,4% Sodium Bicarbonate), respectively. After 24h of the last administration, the animals were submitted to the following behavior tests: Open Field (OP); Rotarod, Forced Swim (FS) and Elevated Plus Maze (EPM). This study was approved by Ethics Committee on the Use of Animals of the Federal University of Ceará (CEUA), under protocol number 1977300718. The results showed a reduction in the Crossing number, in OP test, but no difference of motor performance in the Rotarod test, an increase of the immobility time in the NF, however there was no significant difference between the groups in the analyzed parameters for EPM. Hence, it suggests that Omeprazole triggered depressive-like behavior, which was evidenced by Immobility Time increase in the NF, however, without a presence of an anxious behavior. Considering the results of current study and other research already published about Omeprazole effects in the CNS, it’s necessary more researches to be done, in order to understand the mechanisms involved and the important to foster the rational use of this common drug.