Estudo da indução assimétrica na síntese de precursores de aminoácidos não-naturais via adição de Michael sob condições de catálise de transferência de fase (CTF)

Abstract

The addition reaction under asymmetric phase transfer catalysis (PTC) of acetylamine Ia to α-enone IIa (Scheme I), using N-benzylmethylephedrinium bromide 31a, reported in the literature, afforded the Michael adduct with 56% yeld and 60% of enatiomeric excess (e.e.). However when the same reaction was performed, by us, in the presence of a derivative of catalyst 31a, which a hydroxyl group was protected via O-allylation (catalyst 120), the Michael adduct was obtained with 52% yeld, but with low asymmetric induction. [...]