Please use this identifier to cite or link to this item: http://repositorio.ufc.br/handle/riufc/71502
Type: Artigo de Periódico
Title: Structure elucidation and anticancer activity of 7-Oxostaurosporine derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei.
Authors: Jimenez, Paula Christine
Wilke, Diego Veras
Ferreira, Elthon Gois
Takeara, Renata
Moraes, Manoel Odorico de
Silveira, Edilberto Rocha
Lotufo, Tito Monteiro da Cruz
Lopes, Norberto Peporine
Costa-Lotufo, Leticia Veras
Keywords: Cell cycle;Species - Ascidiacea;Staurosporine;ciclo celuar;Espécie - Ascidiacea;Cefalsoporina
Issue Date: 2012
Publisher: Marine Drugs
Citation: JIMENEZ, Paula Christine; WILKE, Diego Veras; FERREIRA, Elthon Gois; TAKEARA, Renata.; MORAES, Manoel Odorico de; SILVEIRA Edilberto Rocha da ; LOTUFO, Tito Monteiro da Cruz; LOPES, Norberto Peporine; COSTA-LOTUFO, L. Veras. Structure elucidation and anticancer activity of 7-Oxostaurosporine derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei. Marine Drugs, Switzerland,v.10, n.5, p. 1092-1102, 2012. Disponível em: https://doi.org/10.3390/md10051092. Acesso em: 30 mar. 2023.
Abstract: he present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC50 values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay. Keywords:
URI: http://www.repositorio.ufc.br/handle/riufc/71502
ISSN: 1660-3397
Appears in Collections:LABOMAR - Artigos publicados em revistas científicas

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