Ação inseticida dos inibidores de proteases presentes em plantas contra o Aedes aegypti: uma revisão bibliográfica

Abstract

The Aedes aegypti mosquito is the main vector of some arboviruses belonging to the Flaviviridae family and the Flavivirus genus, such as yellow fever, Zika and dengue. Among these arboviruses, Dengue is the most worrisome worldwide, due to its resurgence and the increase in its vector incidence areas. The use of chemical insecticides to combat this vector has been compromised by the resistant populations arising and the damage caused to the environment. Thus, there has been an increase in the search for novel alternatives to combat this vector, among which plant proteins with insecticidal potential have been studied, more specifically the one addressed in this study which are proteinase inhibitors. The present study aimed to carry out a literature review on protease inhibitors and their insecticidal action against Ae aegypti, in order to seek new updates and scientific evidence. The bibliographic search was carried out in the databases Pubmed, Scielo, Portal Periódicos da CAPES and Science Direct using the descriptors, "Ae. aegypti and protease inhibitor plants" in English, totaling 347 reports found between the years 2002 to 2022, but only 19 works were selected for discussion because they fit the inclusion criteria for this review. After reading the selected works, it can be highlighted that protease inhibitors have insecticidal action against Ae aegypti in its larval stage, however, more studies are needed to clarify precisely how these inhibitors can be used to combat this vector.