Please use this identifier to cite or link to this item: http://repositorio.ufc.br/handle/riufc/64080
Type: Artigo de Periódico
Title: Tropane alkaloids from the stem bark of Erythroxylum bezerrae
Authors: Brito, Luana San de O.
Pinto, Francisco das Chagas L.
Moraes Filho, Manoel Odorico de
Rocha, Danilo D.
Mendoza, Maria Fernanda M.
Ayala, Alejandro Pedro
Bezerra, Beatriz Pinheiro
Loiola, Maria Iracema B.
Canuto, Kirley Marques
Silveira, Edilberto R.
Pessoa, Otilia Deusdenia L.
Keywords: Erythroxylum bezerrae Plowman;Erythroxylaceae;Tropane alkaloids;Cytotoxic activity
Issue Date: 2020
Publisher: Phytochemistry
Citation: BRITO, Luana San de O. et al. Tropane alkaloids from the stem bark of Erythroxylum bezerrae. Phytochemistry, [s. l.], v. 178, p. 1-9, 2020.
Abstract in Brazilian Portuguese: Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC50 values of 3.38 and 5.43 μM for HCT-116 and NCI-H460, respectively
URI: http://www.repositorio.ufc.br/handle/riufc/64080
Access Rights: Acesso Aberto
Appears in Collections:DBIO - Artigos publicados em revista científica

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