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http://repositorio.ufc.br/handle/riufc/64064| Tipo: | Artigo de Periódico |
| Título : | Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission |
| Autor : | Magalhães, Herbert S. Silva, Alison B.da Nascimento, Nilberto Robson Falcão do Sousa, Luis Gustavo F. de Fonseca, Maria Júlia S. da Loiola, Maria Iracema B. Monteiro, Norberto K. V. Almeida Neto, Francisco Wagner de Queiroz Canuto, Kirley Marques Pessoa, Otilia Deusdênia L. |
| Palabras clave : | Rauvolfia ligustrina;Indole alkaloids;Neuroinhibitory effect;GIAO 13C NMR |
| Fecha de publicación : | 2020 |
| Editorial : | Fitoterapia |
| Citación : | MAGALHÃES, Herbert S. et al. Effect of indole alkaloids from roots of Rauvolfia ligustrina in the noradrenergic neurotransmission. Fitoterapia, [s. l.], v. 143, p. 1-7, 2020. |
| Resumen en portugués brasileño: | The new glucosyl sarpagan alkaloid designated as 21(R*)-(O-β-glucosyl)-hydroxy-sarpagan-17-oic acid, along with eleven known alkaloids were isolated from a soluble alkaloidal fraction from the ethanol extract of Rauvolfia ligustrina. Their structures were elucidated by interpretation of spectroscopic data (1D and 2D NMR), HRESIMS experiment, GIAO 13C NMR calculations, and comparison with literature data. All the isolated alka- loids were screened by their neuroinhibitory effects using the electrically stimulated mice vas deferens bioassay. Compounds 1, 2 and 9 presented a potent inhibitory effect in the neurotransmission while 3 and 11 showed an acute neuroexcitatory effect. Compound 10 exhibited a very effective post-synaptic inhibitory activity |
| URI : | http://www.repositorio.ufc.br/handle/riufc/64064 |
| Derechos de acceso: | Acesso Aberto |
| Aparece en las colecciones: | DBIO - Artigos publicados em revista científica |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| 2020_art_hsmagalhães.pdf | 4,71 MB | Adobe PDF | Visualizar/Abrir |
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