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Type: Artigo de Periódico
Title: Omega-3 fatty acids : possible ceuroprotective mechanisms in the model of global ischemia in rats
Authors: Nobre, Maria Elizabeth Pereira
Correia, Alyne Oliveira
Mendonça, Francisco Nilson Maciel
Uchoa, Luiz Ricardo Araújo
Vasconcelos, Jessica Tamara Nunes
Araújo, Carlos Ney Alencar de
Brito, Gerly Anne de Castro
Siqueira, Rafaelly Maria Pinheiro
Cerqueira, Gilberto dos Santos
Neves, Kelly Rose Tavares
Arida, Ricardo Mário
Viana, Glauce Socorro de Barros
Keywords: Fármacos Neuroprotetores;Neuroprotective Agents;Isquemia;Ischemia
Issue Date: 2016
Publisher: Journal of Nutrition and Metabolism
Citation: NOBRE, M. E. P. et al. Omega-3 fatty acids : possible neuroprotective mechanisms in the model of global ischemia in rats. Journal of Nutrition and Metabolism, v. 2016, p. 1-13, 2016.
Abstract: Background. Omega-3 (3) administration was shown to protect against hypoxic-ischemic injury. The objectives were to study the neuroprotective effects of 3, in a model of global ischemia. Methods. Male Wistar rats were subjected to carotid occlusion (30 min), followed by reperfusion. The groups were SO, untreated ischemic and ischemic treated rats with 3 (5 and 10 mg/kg, 7 days). The SO and untreated ischemic animals were orally treated with 1% cremophor and, 1 h after the last administration, they were behaviorally tested and euthanized for neurochemical (DA, DOPAC, and NE determinations), histological (Fluoro jade staining), and immunohistochemical (TNF-alpha, COX-2 and iNOS) evaluations. The data were analyzed by ANOVA and Newman-Keuls as the post hoc test. Results. Ischemia increased the locomotor activity and rearing behavior that were partly reversed by 3. Ischemia decreased striatal DA and DOPAC contents and increased NE contents, effects reversed by 3. This drug protected hippocampal neuron degeneration, as observed by Fluoro-Jade staining, and the increased immunostainings for TNF-alpha, COX-2, and iNOS were partly or totally blocked by 3. Conclusion. This study showed a neuroprotective effect of 3, in great part due to its anti-inflammatory properties, stimulating translational studies focusing on its use in clinic for stroke managing.
ISSN: 2090-0724
Appears in Collections:PPGF - Artigos publicados em revistas científica

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