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dc.contributor.authorNobre, Maria Elizabeth Pereira-
dc.contributor.authorCorreia, Alyne Oliveira-
dc.contributor.authorMendonça, Francisco Nilson Maciel-
dc.contributor.authorUchoa, Luiz Ricardo Araújo-
dc.contributor.authorVasconcelos, Jessica Tamara Nunes-
dc.contributor.authorAraújo, Carlos Ney Alencar de-
dc.contributor.authorBrito, Gerly Anne de Castro-
dc.contributor.authorSiqueira, Rafaelly Maria Pinheiro-
dc.contributor.authorCerqueira, Gilberto dos Santos-
dc.contributor.authorNeves, Kelly Rose Tavares-
dc.contributor.authorArida, Ricardo Mário-
dc.contributor.authorViana, Glauce Socorro de Barros-
dc.identifier.citationNOBRE, M. E. P. et al. Omega-3 fatty acids : possible neuroprotective mechanisms in the model of global ischemia in rats. Journal of Nutrition and Metabolism, v. 2016, p. 1-13, 2016.pt_BR
dc.description.abstractBackground. Omega-3 (3) administration was shown to protect against hypoxic-ischemic injury. The objectives were to study the neuroprotective effects of 3, in a model of global ischemia. Methods. Male Wistar rats were subjected to carotid occlusion (30 min), followed by reperfusion. The groups were SO, untreated ischemic and ischemic treated rats with 3 (5 and 10 mg/kg, 7 days). The SO and untreated ischemic animals were orally treated with 1% cremophor and, 1 h after the last administration, they were behaviorally tested and euthanized for neurochemical (DA, DOPAC, and NE determinations), histological (Fluoro jade staining), and immunohistochemical (TNF-alpha, COX-2 and iNOS) evaluations. The data were analyzed by ANOVA and Newman-Keuls as the post hoc test. Results. Ischemia increased the locomotor activity and rearing behavior that were partly reversed by 3. Ischemia decreased striatal DA and DOPAC contents and increased NE contents, effects reversed by 3. This drug protected hippocampal neuron degeneration, as observed by Fluoro-Jade staining, and the increased immunostainings for TNF-alpha, COX-2, and iNOS were partly or totally blocked by 3. Conclusion. This study showed a neuroprotective effect of 3, in great part due to its anti-inflammatory properties, stimulating translational studies focusing on its use in clinic for stroke managing.pt_BR
dc.publisherJournal of Nutrition and Metabolismpt_BR
dc.subjectFármacos Neuroprotetorespt_BR
dc.subjectNeuroprotective Agentspt_BR
dc.titleOmega-3 fatty acids : possible ceuroprotective mechanisms in the model of global ischemia in ratspt_BR
dc.typeArtigo de Periódicopt_BR
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