Prevalência de traço falciforme em estudantes do curso de Farmácia da Universidade Federal do Ceará

Abstract

Sickle cell trait (TF) is a relatively common genetic condition, but clinically benign constituted by heterozygous hemoglobin S due to transmission βS globin gene from one parent, along with βA globin another. The great migration of people for different regions of Brazil contributed to increased racial miscegenation, causing the spread of hemoglobin S gene in the country, which has become more common where there is a higher proportion of African ancestry as the North and Northeast regions, and lower in the south and southeast. This study aimed to assess the prevalence of sickle cell trait in a sample of students enrolled in the course of Pharmacy, Federal University of Ceará (UFC). The sample consisted of 120 students of the Pharmacy course of the UFC, of both sexes, aged between 19 and 37 years. We conducted research of hemoglobin S by hemoglobin electrophoresis and those who showed presence of Hb were confirmed by solubility test and HPLC. The prevalence of sickle cell trait was 2.5% and 1.67% of males and 0.83% of females. The present study showed prevalence consistent with the average found in the country, which confirms the importance of early completion of the trace diagnosis.