Uso do antioxidante tópico da Terminalia catappa linn (castanhola) como tratamento de acne vulgar em graus II e III

Abstract

Introduction: Acne vulgaris is a very prevalent skin condition, the cause of its pathogenesis is multifactorial and involves excess sebum production, desquamation of the follicular epithelium, presence of Cutibacterium acnes and inflammation. Oxidative stress is believed to have adverse effects on inflammation and tissue damage and can lead to acne symptoms. In this sense, exploring natural resources can be a therapeutic alternative. Objective: To evaluate the effect of 4% Terminalia Capatta Linn (chestnut) extract gel on patients with grade II and III acne vulgaris. Methods: This was a non-randomized clinical trial, carried out from May to September 2023 with a total of eighteen women, divided equally into Control Group (CG) and Treatment Group (GI). The CG received only one punctual skin cleansing and the TG underwent eight treatments, twice a week using 4% castanet extract and were then reevaluated through the DLQI, photographic records and satisfaction questionnaire and improves the skin. Results: Both groups were homogeneous. There was an improvement in facial dermatofunctional changes in both groups, but in the GT they were statistically more significant (p<0.001). There was an improvement in the degree of acne (p<0.001) and quality of life assessed by the DLQI (p<0.05). Finally, there was an improvement in the self-reported general appearance of the skin. Conclusion: The use of castanet extract applied twice a week for four weeks was effective for treating grade II and III acne, however, more studies are needed.