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http://repositorio.ufc.br/handle/riufc/72270| Type: | Artigo de Periódico |
| Title: | New alkaloids from margaritopsis carrascoana (rubiaceae) |
| Authors: | Nascimento, Raimundo Regivaldo Gomes do Pimenta, Antônia Torres Ávila Lima Neto, Pedro de Cândido Júnior, José Roberval Lotufo, Leticia Veras Costa Ferreira, Elthon Gois Tinoco, Luzineide Wanderley Braz Filho, Raimundo Silveira, Edilberto Rocha Lima, Mary Anne Sousa |
| Keywords: | Margaritopsis carrascoana;Rubiaceae alkaloids;N-8”-methyl-N-1’-demethyl- iso-calycosidine;Margaritopsis carrascoana;Alcaloides de rubiaceae |
| Issue Date: | 2015 |
| Publisher: | Journal of the Brazilian Chemical Society |
| Citation: | NASCIMENTO, Raimundo Regivaldo Gomes do; PIMENTA, Antônia Torres Ávila; LIMA NETO, Pedro de; CÂNDIDO JÚNIOR, José Roberval; LOFUTO, Leticia Veras Costa; FERREIRA, Elthon Gois; TINOCO, Luzineide Wanderley; BRAZ FILHO, Raimundo; SILVEIRA, Edilberto Rocha; LIMA, Mary Anne Sousa. New alkaloids from margaritopsis carrascoana (rubiaceae). Journal of the Brazilian Chemical Society, v. 26, n. 6, p. 1152-1159, 2015. |
| Abstract: | Two new alkaloids containing Nb-methyl-triptamine units linked to bis-quinoline moieties, N-8”-formyl-calycosidine and N-8”-methyl-N-1’-demethyl-iso-calycosidine, were isolated from the aerial part of Margaritopsis carrascoana, along with known calycosidine and hodgkinsine. The cytotoxicity of the isolated alkaloids has been evaluated against cancer cell lines. The first two compounds showed only weak activity against HL-60 cell line, while hodgkinsine was the most active compound against HCT-116, OVCAR-8, HL-60 and SF-295 cancer cell lines. The structures of the isolated compounds were established by spectroscopic and molecular mechanical methods. |
| URI: | http://www.repositorio.ufc.br/handle/riufc/72270 |
| ISSN: | 1678-4790 |
| Appears in Collections: | DEME - Artigos publicados em revista científica |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2015_art_plimaneto.pdf | 468,31 kB | Adobe PDF | View/Open |
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