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http://repositorio.ufc.br/handle/riufc/64080| Type: | Artigo de Periódico |
| Title: | Tropane alkaloids from the stem bark of Erythroxylum bezerrae |
| Authors: | Brito, Luana San de O. Pinto, Francisco das Chagas L. Moraes Filho, Manoel Odorico de Rocha, Danilo D. Mendoza, Maria Fernanda M. Ayala, Alejandro Pedro Bezerra, Beatriz Pinheiro Loiola, Maria Iracema B. Canuto, Kirley Marques Silveira, Edilberto R. Pessoa, Otilia Deusdenia L. |
| Keywords: | Erythroxylum bezerrae Plowman;Erythroxylaceae;Tropane alkaloids;Cytotoxic activity |
| Issue Date: | 2020 |
| Publisher: | Phytochemistry |
| Citation: | BRITO, Luana San de O. et al. Tropane alkaloids from the stem bark of Erythroxylum bezerrae. Phytochemistry, [s. l.], v. 178, p. 1-9, 2020. |
| Abstract in Brazilian Portuguese: | Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC50 values of 3.38 and 5.43 μM for HCT-116 and NCI-H460, respectively |
| URI: | http://www.repositorio.ufc.br/handle/riufc/64080 |
| Access Rights: | Acesso Aberto |
| Appears in Collections: | DBIO - Artigos publicados em revista científica |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2020_art_lsbrito.pdf | 6,03 MB | Adobe PDF | View/Open |
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