Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.ufc.br/handle/riufc/59698
Tipo: Artigo de Periódico
Título : Combined transcriptomic and proteomic analysis reveals a diversity of venom‑related and toxin‑like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia)
Título en inglés: Combined transcriptomic and proteomic analysis reveals a diversity of venom‑related and toxin‑like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia)
Autor : Liao, Qiwen
Gong, Guiyi
Poon, Terence C. W.
Ang, Irene L.
Lei, Kate M. K.
Siu, Shirley Weng In
Wong, Clarence Tsun Ting
Rádis-Baptista, Gandhi
Lee, Simon Ming Yuen
Palabras clave : Veneno;Neuroproteção;Aminoácidos
Fecha de publicación : 2019
Editorial : Archives of Toxicology
Citación : LIAO, Qiwen; GONG, Guiyi; POON, Terence C. W.; ANG, Irene L. Ang; LEI, Kate M. K.; SIU, Shirley Weng In; WONG,jClarence Tsun Ting; RÁDIS BAPTISTA, Gandhi; LEE, Simon Ming Yuen . Combined transcriptomic and proteomic analysis reveals a diversity of venom related and toxin like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia). Archives of Toxicology, Germany, v. 93, p. 1745–1767. 2019.
Abstract: Venoms from marine animals have been recognized as a new emerging source of peptide-based therapeutics. Several peptide toxins from sea anemone have been investigated as therapeutic leads or pharmacological tools. Venom complexity should be further highlighted using combined strategies of large-scale sequencing and data analysis which integrated transcriptomics and proteomics to elucidate new proteins or peptides to be compared among species. In this work, transcriptomic and proteomic analyses were combined to identify six groups of expressed peptide toxins in Zoanthus natalensis. These include neurotoxin, hemostatic and hemorrhagic toxin, protease inhibitor, mixed function enzymes, venom auxiliary proteins, allergen peptides, and peptides related to the innate immunity. Molecular docking analysis indicated that one expressed Zoanthus Kunitz-like peptide, ZoaKuz1, could be a voltage-gated potassium channels blocker and, hence, it was selected for functional studies. Functional bioassays revealed that ZoaKuz1 has an intrinsic neuroprotective activity in zebrafsh model of Parkinson’s disease. Since pharmacological blockade of KV channels is known to induce neuroprotective efects, ZoaKuz1 holds the potential to be developed in a therapeutic tool to control neural dysfunction by slowing or even halting neurodegeneration mediated by ion-channel hyperactivity
URI : http://www.repositorio.ufc.br/handle/riufc/59698
ISSN : 0340-5761
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