Please use this identifier to cite or link to this item:
http://repositorio.ufc.br/handle/riufc/5772| Type: | Artigo de Periódico |
| Title: | Venom’s antinociceptive property in the primitive ant Dinoponera quadriceps |
| Authors: | Sousa, Paloma L. Quinet, Yves Patric Ponte, Edson L. Vale, Jaqueline F.do Torres, Alba Fabíola C. Pereira, Maria G. Assreuy, Ana Maria S. |
| Keywords: | Venenos de Formiga;Doenças Reumáticas |
| Issue Date: | Oct-2012 |
| Publisher: | Journal of Ethnopharmacology |
| Citation: | SOUSA, P. L. et al. Venom's antinociceptive property in the primitive ant Dinoponera quadriceps. Journal of Ethnopharmacology, Lausanne, Suiça, v. 144, n. 1, p. 213-216, out. 2012. |
| Abstract: | Ethnopharmacologicalrelevance: In northeasternBrazil, Dinoponera (Ponerinae)antsmacerateareused to treatearacheanditssting,rheumatism,andbackpain.Suchapopularuseisarelevantfactthat called forexperimentalevaluationoftheantinociceptiveactivityof Dinoponera venom. Materialsandmethods:Dinoponeraquadriceps venom(DqV;5–500 mg/kg;i.v.)ormorphine(3.4mg/kg;s.c.) wereevaluatedinmicemodelsofnociception(n¼8 animals/group).Negativecontrolsreceivedsterilesaline (0.9%NaCl;i.v.). Results: DqVshowed64%proteincontentandexhibitedantinociceptiveactivity,withoutaffectingmotor function,inthetests:formalin(72%),writhing(52%),vonFrey(71%)andhotplate(45%).Theantinociceptive activitywasabolishedunderproteindenaturantconditions. Conclusions: Thisstudyprovidedthefirstdemonstrationoftheantinociceptivepropertyof Dinoponera quadriceps venominmicemodelsofchemical,mechanical and thermalnociception,corroboratingthe popularuseandsuggestingitspotentialtherapeuticutilizationinpainfulconditions. |
| URI: | http://www.repositorio.ufc.br/handle/riufc/5772 |
| ISSN: | 0378-8741 |
| Appears in Collections: | DFAR - Artigos publicados em revistas científicas |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2012_art_afctorres.pdf | 212,7 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.