Estudo epidemiológico da doença de Cushing no Hospital Universitário Walter Cantídio

Abstract

Objectives: To evaluate the epidemiology of patients with Cushing’s disease who are followed at the Hospital Universitário Walter Cantídio (HUWC) and compare our data with that of the current literature. Methods: An observational, longitudinal and retrospective study was carried out, including patients with current or previous Cushing’s Disease (DC) follow-up at the HUWC Endocrinology Service. Data analysis was performed by the SPSS program, and the significance level adopted for the statistical tests was 5% (p <0.05). The project was submitted, through the Brazil Platform, to the Ethics and Research Committee of the HUWC. Results: A higher prevalence of lesions smaller than 1cm was observed. Most patients underwent transsphenoidal surgery as first-line therapy. The control in the first 6 months of disease was obtained in 71.42% of the patients who performed some type of surgery, but with an important relapse rate. Conclusions: In the present study, a high incidence of recurrence was observed after first-line treatment. Due to the high morbidity and therapeutic response, not always desired in first-line treatments, DC is still quite challenging for the endocrinologist. Long-term follow-up of these patients is important.