Please use this identifier to cite or link to this item:
http://repositorio.ufc.br/handle/riufc/49653| Type: | Artigo de Periódico |
| Title: | An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor |
| Authors: | Martins, Ana Caroline Vieira Lima Neto, Pedro de Barroso Neto, Ito Liberato Cavada, Benildo Sousa Freire, Valder Nogueira Caetano, Ewerton Wagner Santos |
| Keywords: | Central nervous system;Amino acids;Electrophysiological |
| Issue Date: | 2013 |
| Publisher: | RSC Advances |
| Citation: | MARTINS, Ana Caroline Vieira; LIMA-NETO, Pedro de; NETO, Ito Liberato Barroso; CAVADA, Benildo Sousa; FREIRE, Valder Nogueira; CAETANO, Ewerton Wagner Santos. An ab initio explanation of the activation and antagonism strength of an AMPA-sensitive glutamate receptor. RSC Advances, v. 3, n. 35, p. 1-5, 2013. |
| Abstract: | We report quantum biochemistry calculations focusing on the binding pocket of the glutamate receptor co-crystallized with agonists (full and partial) and a antagonist. The calculated electronic binding energy follows the order AMPA . glutamate. kainate . DNQX, which explains published experimental data on GluR2 activation and antagonism strength. |
| URI: | http://www.repositorio.ufc.br/handle/riufc/49653 |
| ISSN: | 2046-2069 |
| Access Rights: | Acesso Aberto |
| Appears in Collections: | DFI - Artigos publicados em revista científica |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2013_art_acvmartins.pdf | 585,42 kB | Adobe PDF | View/Open |
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