Extração comparativa de compostos fenólicos e outros minoritários em phyllanthus amarus e phillanthus niruri por UPLC-QTOF-MS/MS e análise quimiométrica

Abstract

Phyllanthus amarus and Phyllanthus niruri are species of medicinal plants, popularly known as “quebra-pedra”, commonly used in folk medicine in tropical and subtropical countries, such as India, Brazil and Malaysia. They are used to cure pathologies such as hepatitis B, kidney stones, diabetes and other infectious diseases. Their medicinal properties are due to the presence of phenolic compounds in their composition. This study aimed to achieve the best extraction method, whether it was by ultrasound or maceration, and solvent proportion for a better extraction of phenolic compounds. The extracts were prepared with pure water and different methanol/water and ethanol/water ratios to be analysed by ultra performance liquid chromatography coupled to mass spectrometry (UPLC-QTOF-MS/MS) system and by chemometrics for a more detailed information.