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Type:	Artigo de Periódico
Title:	Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby
Authors:	Roomruangwong, Chutima Barbosa, Decio Sabbatini Matsumoto, Andressa Keiko Nogueira, André de Souza Kanchanatawan, Buranee Sirivichayakul, Sunee Carvalho, André Ferrer Duleu, Sebastien Geffard, Michel Moreira, Estefania Gastaldello Maes, Michael
Keywords:	Depression;Inflammation;Complexo Antígeno-Anticorpo (Immune)
Issue Date:	Dec-2017
Publisher:	Journal of Affective Disorders
Citation:	ROOMRUANGWONG, CHUTIMA et al. Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby. Journal of Affective Disorders, v. xx, p. 49-58, dez. 2017.
Abstract in Brazilian Portuguese:	Objectives: To examine oxidative & nitrosative stress (O & NS) biomarkers at the end of term in relation to perinatal affective symptoms, neuro-immune biomarkers and pregnancy-related outcome variables. Methods: We measured plasma advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical trapping antioxidant parameter (TRAP), -sulfhydryl (-SH), peroxides (LOOH) and paraoxonase (PON)1 activity in pregnant women with and without prenatal depression and non-pregnant controls. Results: Pregnancy is accompanied by significantly increased AOPP and NOx, and lowered TRAP, -SH and LOOH. Increased O & NS and lowered LOOH and -SH levels are associated with prenatal depressive and physiosomatic symptoms (fatigue, pain, dyspepsia, gastro-intestinal symptoms). Increased AOPP and NOx are significantly associated with lowered –SH, TRAP and zinc, and with increased haptoglobin and C-reactive protein levels. Increased O & NS and lowered TRAP and PON 1 activity, at the end of term predict mother (e.g. hyperpigmentation, labor duration, caesarian section, cord length, breast milk flow) and baby (e.g. sleep and feeding problems) outcome characteristics. Conclusions: Pregnancy is accompanied by interrelated signs of O & NS, lowered antioxidant defenses and activated neuro-immune pathways. Increased O & NS at the end of term is associated with perinatal depressive and physio-somatic symptoms and may predict obstetric and behavioral complications in mother and baby.
URI:	http://www.repositorio.ufc.br/handle/riufc/25133
ISSN:	0165-0327
Appears in Collections:	DMC - Artigos publicados em revistas científicas

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