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http://repositorio.ufc.br/handle/riufc/18047| Type: | Artigo de Periódico |
| Title: | Anti-inflammatory and anti-resorptive effects of atorvastatin on alveolar bone loss in wistar rats |
| Authors: | Goes, Paula Lima, Neiberg Alcântara Rodrigues, José Ariévilo Gurgel Benevides, Norma Maria Barros Brito, Gerly Anne Castro Lima, Vilma |
| Keywords: | Periodontite;Fosfatase Alcalina |
| Issue Date: | May-2016 |
| Publisher: | Brazilian Dental Journal |
| Citation: | GOES, P. et al. Anti-inflammatory and anti-resorptive effects of atorvastatin on alveolar boneloss in wistar rats. Brazilian Dental Journal, Ribeirão Preto, v. 27, n. 3, p. 267-272, may./jun. 2016. |
| Abstract in Brazilian Portuguese: | O objetivo do estudo foi avaliar o efeito anti-inflamatório e anti-reabsortivo da atorvastatina (ATV) no modelo de perda óssea alveolar experimental (POA). Para isto, ratos Wistar foram submetidos a inserção de ligadura ao redor do segundo molar maxilar durante 11 dias. Os animais receberam diariamente, por gavagem, soro fisiológico a 0,9% (2 mg/kg) ou ATV (0,3, 3 ou 27 mg/kg). A POA foi avaliada pela área de reabsorção e análise histológica. Dosagens séricas da atividade de fosfatase alcalina óssea foram avaliadas. Leucograma foi realizado a 0 h, na 6a h, 2o, 7o e 11o dias. Foram analisadas condições de rim, fígado e variação de massa corpórea. As ATV (3 e 27 mg/kg) inibiram POA em 39% e 56%, respectivamente. A análise histopatológica mostrou que a ATV 27 mg/kg preveniu POA e reabsorção de cemento, e o infiltrado celular inflamatório induzido por ligadura. ATV (27 mg/kg) preveniu a redução dos níveis séricos de fosfatase alcalina óssea. ATV (27 mg/kg) preveniu leucocitose e não afetou função renal e hepática ou o peso corporal. ATV mostrou um efeito protetor na periodontite induzida por ligadura, sem afetar os parâmetros sistêmicos, através da inibição do processo inflamatório e pela atividade anabólica no osso alveolar. |
| Abstract: | The aim of this study was to evaluate the anti-inflammatory and anti-resorptive effect of atorvastatin (ATV) in an experimental alveolar bone loss (ABL) model. Wistar rats were subjected to ligature placement around the maxillary second molar for 11 days. The animals received 0.9% saline (2 mL/kg) or ATV (0.3, 3 or 27 mg/kg) daily by gavage. ABL was evaluated by resorption area and histopathological analysis. Serum bone-specific alkaline phosphatase (BALP) activity was also evaluated. Leukogram was performed at 0 h, 6th h, 2nd, 7th and 11th days. Kidney and liver conditions and the body mass variation were analyzed. ATV (3 and 27 mg/kg) inhibited ABL by 39% and 56%, respectively. Histopathological analysis showed that ATV 27 mg/kg prevented ABL and cemental resorption, and inflammatory cell infiltration induced by ligature. ATV (27 mg/kg) prevented serum BALP levels reduction. ATV (27 mg/kg) prevented leukocytosis and did not affect either kidney or liver function nor body mass weight. ATV showed a protecting effect in the ligature-induced periodontitis, without affecting system parameters, by inhibition of inflammatory process and by its anabolic activity on the alveolar bone |
| URI: | http://www.repositorio.ufc.br/handle/riufc/18047 |
| ISSN: | Print version 0103-6440 On-line 1806-4760 |
| Appears in Collections: | DCOD - Artigos publicados em revistas científicas |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2016_art_pgoes.pdf | 732,13 kB | Adobe PDF | View/Open |
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