Desenvolvimento e estudo de estabilidade preliminar de uma emulsão repelente contendo bioativos do líquido da castanha de caju

Abstract

Concern about the increase in the spread of insect-borne diseases has promoted the encouragement of many researches to control thes evectorsand also for the treatment and prevention of arboviruses. In this way, the use of repellents has been widely propagated and is one of the main measures of personal protection against mosquito bites. The assets of these products maybe of synthetic or vegetable origin, the latter being derived from the secondary metabolites of plants.Among the several bioactives that have been used and recognized historically, liquid cashew nutshell (CNSL) has been studied extensively andis a product of a plant species very comun in the northeastern region of Brazil. The CNSL source of phenolic compounds and unsaturated long chain and main constituents Cardanol and Cardol. The presente work aims to develop repellent and perform preliminary stability tests of the formula. For this, repellency tests were performed in white miceandstudies with humansusingLCC Natural, technical, and Cardol Cardanol comparing its activity to a commercial repellent N, N-dimethyl-meta-toluamide (DEET).In tests using mice, the product showed the percentage of repellency of 98% to 100% compared with the pure moisturizer. Furthermore, in studies with humans, it has been found that the Natural CNSL was repellency of 93.8%, followed by 92.4% cardol. These values have proved to be equivalent to the percentage of commercial repellent DEET (93.6%). Being the most effective LCC Natural, it was used in the preparation of the repellent formulation and subjected to the preliminary stability tests described in Anvisa's Guide to Stability of Cosmetic Products. Half the samples were stored at room temperature and the other half inside a 40 ° C oven, and several parameters were assessed. The study was 15 days-long and the assessed parameters were: organoleptic properties (appearance, color and odor), centrifugation, determination of pH, viscosity and spreadability. The samples showed satisfactory results in preliminary stability tests, because its organoleptic and physicochemical properties were preserved throughout the test period. In addition, determination of stirring speed demonstrated that at speeds greater than 500 rpm, it imparted negative aspects in the development of the emulsion.