Potencial cicatrizante de uma biomembrana composta de proteínas do látex de Calotropis procera no tratamento de úlceras venosas: ensaio clínico piloto

Abstract

Venous ulcers are a significant public health problem, associated with high morbidity rates and impact on patients' quality of life. These plantar ulcers require prolonged and costly treatments, with frequent dressing changes, which can increase costs for patients. BioMemCpLP is a biomembrane composed of proteins isolated from Calotropis procera latex, combined with polyvinyl alcohol, and has already demonstrated healing properties in chronic lesions, such as those resulting from leprosy and diabetic foot, in addition to being low cost. This study aimed to evaluate the efficacy of BioMemCpLP in the healing of venous ulcers through a pilot, observational, prospective, monocentric and active-controlled clinical trial. The research included the participation of seven volunteers, randomly divided into control and test groups; the control group received treatment with the foam dressing, and the test group with BioMemCpLP. The results confirmed the higher prevalence of venous ulcers in elderly women, often associated with comorbidities such as hypertension and diabetes. Patients treated with the biomembrane showed an average reduction of 36.45% in the ulcer area, accompanied by less exudation and greater re-epithelialization. In one of the cases, complete healing was observed. No patient in the treated group showed worsening of the lesion area, unlike what was observed in the control group. The findings suggest that BioMemCpLP is a promising alternative for the treatment of venous ulcers, demonstrating clinical benefits in reducing the lesion and promoting healing, when compared to the conventional method. Additional studies with larger samples are recommended to validate these findings and expand their clinical applicability.