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http://repositorio.ufc.br/handle/riufc/7232| Type: | Artigo de Periódico |
| Title: | Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells: involvement of NAD(P)H :quinone oxidoreductase (NQO1) |
| Authors: | Cavalcanti, Bruno C. Magalhães, Hemerson I. F. Rodrigues, Felipe A. R. Moraes Filho, Manoel Odorico de Pessoa, Cláudia |
| Keywords: | Apoptose;Neoplasias da Próstata |
| Issue Date: | Apr-2013 |
| Publisher: | BMC Proceedings |
| Citation: | CAVALCANTI, B. C. et al. Arylamino-nor-b-lapachone derivative-induced apoptosis in human prostate cancer cells : involvement of NAD(P)H quinone oxidoreductase (NQO1). BMC Proceedings, São Paulo, SP, v. 7, supl. 2, p. 12-12, abr. 2013. |
| Abstract: | b-lapachone, a DNA repair inhibitor, has been recognized as important prototype with activity against cancer cells devoided of cytotoxicity in non-tumor cells. NQO1 is a reductive enzyme that is important for the activation of many bioreductive quinones. Thus, differential levels of NQO1 in tissues, including tumors, can provide a target for an enzyme-directed approach to cancer therapy. Herein, we aimed to evaluate the role of NQO1 on the cytotoxicity of 3-arylamino-nor-b-lapachone derivative using the prostate DU-145 (NQO1-overexpressing) and LNCap (NQO1-deficient) cells. |
| URI: | http://www.repositorio.ufc.br/handle/riufc/7232 |
| Appears in Collections: | DFIFA - Artigos publicados em revista científica |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2013_art_bccavalcanti.pdf | 160,74 kB | Adobe PDF | View/Open |
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