Concentrações de interleucina-6 em sangue periférico de pacientes com tuberculose pulmonar sensível ou multirresistente aos tuberculostáticos

Abstract

Interleukin-6 (IL-6) plasmatic concentration was studied in 38 patients with active pulmonary tuberculosis. Twenty-three were very sensitive to the specific drug (TBS), while 25 were multiresistant (TBMR). The purpose of this study was to identify the immunological difference between both groups based on the dosage of this interleukin and to compare with that of 63 helthy blood donnors from HEMOCE. The group of patients was seiected from the reference centers D. Libânia, Messejana Hospital and Maracanaú Hospital. TBS group was composed by 16 males (73.9%) and 7 females (26.1%), and TBMR group was composed by 9 males (60%) and 6 females (40%). Control group was composed by 51 males (81%) and 12 females (19%). An ELISA was proceeded to quantify plasmatic concentrations of IL-6 and the results showed a signiffícant increase of IL-6 concentration in tuberculosis patients (6.00 pg/mL) when compared to that of healthy individuais (0.68 pg/mL, p < 0,0001). Additionally, IL-6 concentrations were increased in both TBS (6.18 pg/mL) and TBMR (5.74 pg/mL) groups in relation to Controls (p < 0.0001). In contrast, signiffícant differences were not observed between TBS and TBMR groups (p > 0.05). In conclusion, plasmatic IL-6 was increased in pulmonary tuberculosis, independently to specific drug resistance.