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http://repositorio.ufc.br/handle/riufc/7208| Type: | Artigo de Periódico |
| Title: | Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines |
| Authors: | Silva, Mauro G. Camara, Celso A. Silva, Tania M. S. Feitosa, Anderson C. S. Meira, Assuero S. Pessoa, Cláudia |
| Keywords: | Paládio;Neoplasias |
| Issue Date: | Aug-2013 |
| Publisher: | Journal of the Brazilian Chemical Society |
| Citation: | SILVA, M. G. et al. Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotoxic activity against tumor cell lines. Journal of the Brazilian Chemical Society, São Paulo, SP, v. 24, n. 9, p. 1420-1426, ago. 2013. |
| Abstract in Brazilian Portuguese: | Uma série de derivados 2,3-diino-1,4-naftoquinona foi sintetizada a partir do 2,3-dibromo- 1,4-naftoquinona e diversos alquinos terminais funcionalizados usando a reação de acoplamento de Sonogashira catalisada por paládio. Os compostos foram submetidos à avaliação do potencial citotóxico em três linhagens de células tumorais, OVCAR-8 (ovário), PC-3M (próstata) e NCI‑H358M (pulmão), apresentando, no geral, resultados satisfatórios para inibição do crescimento celular. |
| Abstract: | A series of 2,3-diyne-1,4-naphthoquinone derivatives was synthesized from 2,3-dibromo- 1,4-naphthoquinone and various functionalized terminal alkynes using palladium-catalyzed Sonogashira cross-coupling reaction. The diynes were evaluated as potential cytotoxic agents against three tumor cell lines: human ovarian adenocarcinoma (OVCAR-8), human metastatic prostate cancer (PC-3M) and human bronchoalveolar lung carcinoma (NCI-H358M), presenting, in general, satisfactory results for inhibition of cell growth. |
| URI: | http://www.repositorio.ufc.br/handle/riufc/7208 |
| ISSN: | 0103-5053 Impresso 1678-4790 On-line |
| Appears in Collections: | DFIFA - Artigos publicados em revista científica |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2013_art_asmeira.pdf | 352,83 kB | Adobe PDF | View/Open |
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