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http://repositorio.ufc.br/handle/riufc/7193| Type: | Artigo de Periódico |
| Title: | Trachylobane and kaurane diterpenes from Croton floribundus Spreng |
| Authors: | Uchôa, Paula Karina S. Silva Jr., José Nunes da Silveira, Edilberto Rocha Lima, Mary Anne S. Braz-Filho, Raimundo Costa-Lotufo, Letícia Veras Araújo, Ana Jérsia Moraes Filho, Manoel Odorico de Pessoa, Claudia do Ó |
| Keywords: | Diterpenos;Euphorbiaceae |
| Issue Date: | 2013 |
| Publisher: | Química Nova |
| Citation: | UCHÔA, P. K. S. et al. Trachylobane and kaurane diterpenes from Croton floribundus Spreng. Química Nova, São Paulo, v. 36, n. 6, p. 778-782, 2013. |
| Abstract: | A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en- 19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8-11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated. No compounds showed cytotoxic potential with IC50 values greater than 25 mg/mL. Compound 6 was evaluated against five human cancer cell lines, showing moderate effect against three cancer cell lines, MDA-MB-435, HCT-8 and HCT-116, with IC50 values of 14.32, 13.47 and 12.1 mg/mL, respectively. |
| URI: | http://www.repositorio.ufc.br/handle/riufc/7193 |
| ISSN: | 0100-4042 |
| Appears in Collections: | DFIFA - Artigos publicados em revista científica |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2013_art_ajaraujo2.pdf | 1,45 MB | Adobe PDF | View/Open |
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