Sintomas clínicos e sequelas pós covid em pacientes em hemodiálise não vacinados acometidos por sars-cov-2

Abstract

Introduction:Covid-19 is caused by the new coronavirusnamed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). It is transmitted through respiratory droplets that are expelled through coughing, talking or sneezing. Within the clinical symptoms, some people may experience symptoms similar to those of the flu or develop a more serious clinical condition, which may result in sequelae. Patients on hemodialysis or who have a kidney disease are more susceptible to being contaminated, as they usually have other comorbidities. Objective: To retrospectively analyze the clinical symptoms and sequelae of patients from a macro-region of Ceará who undergo hemodialysis and were affected by COVID 19. Method: This is a cross-sectional study with a sample of 25 patients out of a total of 140 in a dialysis center located in the North Region of the state of Ceará. Medical records were used to obtain demographic and clinical data. As for sequelae, data were obtained through a semi-structured interview with information on post-covid 19 sequelae. In addition, Fisher's test was used to investigate the association between symptoms and sequelae variables. The Cochran–Mantel– Haenszel (CMH) test was used to test the variables in the strata. To verify the association between sequelae and symptoms between each drug (Prednisone, Azithromycin and Ivermectrine), the findAssocs function of the tm package, of the R statistical program, was used. with emphasis also on Pearson's Correlation test to verify the correlation between Age and Number of Symptoms, and Age and Number of Sequelae. Results: Regarding the findings of the studies, the prevalent age was 41-59 years, male, with years of study from 8 to 12 years and married marital status. With regard to post-covid symptoms, the most evident were headache, totaling 16.1% followed by fever with 13.4%. As for sequels, the ones that stand out the most were dizziness, numbness and tingling denoting a percentage of 22.9% followed by headache with 20%. As for the medications, with both medications there was no significant improvement in the clinical condition of the patients. At percentage levels, prednisone showed a percentage of 32.6%, azithromycin 39.1 and ivermectrine 28.3%. Conclusion: Among the most prevalent symptoms and sequelae in individuals affected by Covid-19, headache and dyspnea stand out. In addition, in the analyzed medications, there is no improvement in the clinical condition of the patients.