Síntese e caracterização do complexo cis-[Ru(bpy)2(1-meimN)(4-bzpy)](PF6)2 (onde bpy = 2,2’-bipiridina, 1-meimN = 1-metilimidazol e 4-bzpy = 4-benzoilpiridina)

Abstract

Throughout most of science history, the development of medicines and bioactive compounds were almost entirely focused on the investigation of organic molecules. However, a few dec-ades ago, after the discovery and establishment of many coordination compounds in medical treatments, these studies have gained intense interest and new complexes with promising bio-logical properties have emerged. In this regard, the main goal of this work is to synthesize and characterize a new metal complex with formula cis-[Ru(bpy)2(1-meimN)(4-bzpy)](PF6)2, where bpy = 2,2’-bipyridine, 1-meimN = 1-methylimidazole e 4-bzpy = 4-benzoylpyridine. Characterization was held using infrared spectroscopy, electronic spectroscopy, nuclear mag-netic resonance and cyclic voltammetry, with the purpose to support the proposed structure. In order to evaluate initially the possibility that the complex can act as useful PACT agent in cancer treatment, it was carried out spectroscopic monitoring of the complex cis-[Ru(bpy)2(1-meimN)(4-bzpy)](PF6)2 under blue light irradiation (λmax = 460 nm). Based on the observed spectroscopic profiles, it was shown that the metal complex undergoes dissociation of the 4-benzoylpiridine ligant and forms a new complex with formula cis-[Ru(bpy)2(1-meimN)(solvent)]2+, where solvent = water or acetonitrile. This result indicates that the syn-thesized metal complex has interesting biological properties, which can be explored in future investigations.