Síndrome mielodisplásica variante hipoplásica: análise estatística no serviço de transplante de medula óssea do Hospital Universitário Walter Cantídio

Abstract

Objectives: To analyze, in patients with myelodysplastic syndrome (MDS) hypoplastic variant of the Bone Marrow Transplant service, the response to the transplant and perform a comparison with data from the MDS Latin American database. Methodology: Analytical, cross-sectional and retrospective study by analyzing medical records, including all patients diagnosed with MDS undergoing bone marrow transplantation, evaluation of post-transplantation follow-up, overall survival and complications. Comparison with data from the database of the MDS Latin American Society. Statistical analysis using the JAMOVI and MedCalc programs. Results: A total of 13 MDS patients received an allogenic bone marrow transplant, of which 6 had hypoplastic variant, corresponding to 46.15%. Compared to data from the Latin American database, this percentage is only 12.75%. Conclusions: Our service presented a higher frequency of hypoplastic variant MDS than that described in the medical literature, which corresponds to only 10-15%. Of the 6 patients with hypoplastic MDS, two died, reaching 33.3% against 13.5% in the Latin American database. The other transplanted patients are in remission so far with an overall 2-year survival rate of 83.3%, showing good results compared to the world literature.