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http://repositorio.ufc.br/handle/riufc/64102
Tipo: | Artigo de Periódico |
Título : | Cashew apple fiber prevents high fat diet-induced obesity in mice: an NMR metabolomic evaluation |
Autor : | Carvalho, Diana Valesca Silva, Lorena Mara Alexandre Alves Filho, Elenilson de Godoy Santos, Flávia Almeida Lima, Renan Pereira de Viana, Ana Flávia Seraine Custódio Nunes, Paulo Iury Gomes Fonseca, Said Gonçalves da Cruz Melo, Tiago Sousa de Viana, Daniel de Araújo Gallão, Maria Izabel Brito, Edy Sousa de |
Fecha de publicación : | 2019 |
Editorial : | Food & Function |
Citación : | CARVALHO, Diana Valesca et al. Cashew apple fiber prevents high fat diet-induced obesity in mice: an NMR metabolomic evaluation. Food & Function, [s. l.], v. 10, p. 1671-1683, 2019. |
Abstract: | Dietary fiber intake plays an important role in the prevention of obesity. This study aimed at investigating the effect of cashew fiber without low molecular weight compounds (CABwc) on obesity prevention and metabolomics in a murine model of diet-induced obesity. Mice were fed a chow diet (CD), a high-fat diet (HFD) or a high-fat diet supplemented with CABwc (10%) (HFD-CABwc) for 15 weeks. The body weight, abdominal fat, serum glucose levels, insulin and lipid profiles, satiety hormones such as leptin and ghrelin, digestive enzymes such as amylase and lipase, and inflammatory mediators such as TNF-α, IL-6, and adiponectin were measured, in addition to performing serum and hepatic tissue analyses. The metabolomic analysis was based on nuclear magnetic resonance (NMR) spectroscopy of serum and feces. The effects observed with ingestion of CABwc were appetite control and prevention of hyperglycemia, hyperinsulinemia and hypertriglyceridemia, as well as the prevention of the inflammatory process and reduction of liver injury caused by the HFD. In addition, NMR evidenced the presence of SCFAs in serum and feces of mice fed with HFD-CABwc. These findings suggest that CABwc promoted satiety in mice, improving the metabolism of glucose and lipids. Positive effects of obesity prevention may be associated with SCFA production. |
URI : | http://www.repositorio.ufc.br/handle/riufc/64102 |
Derechos de acceso: | Acesso Aberto |
Aparece en las colecciones: | DBIO - Artigos publicados em revista científica |
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Fichero | Descripción | Tamaño | Formato | |
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2019_art_dvcarvalho.pdf | 3,49 MB | Adobe PDF | Visualizar/Abrir |
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