Construção e análise de rede de interação proteína-proteína de leucemia mieloide aguda: busca por novos alvos para a terapia anticâncer

Abstract

Leukemias are among the most complex types of cancer, being widely studied to improve the prognosis and diagnosis, treatment, aiming at greater patient survival. With computational and genomic artifices, it is possible to analyze how proteins related to myeloid leukemias interact in order to predict which ones might become drug targets. Using search engines in databases and in the literature, an acute myeloid leukemia network was made for further analysis with the cytoscape application. 249 AML proteins were obtained. Among them, 45 proteins of interest, with two not having registered drugs, according to the Drug Gene Interaction Database (DGIdb). It was concluded that the methodology used is of scientific interest to deepen the results obtained in the research with more complex analyses.