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http://repositorio.ufc.br/handle/riufc/5570| Type: | Artigo de Periódico |
| Title: | Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae) |
| Authors: | Menezes, Igor Alexandre Côrtes Carvalho, Adriana Andrade Antoniolli, Angelo Roberto Santos, Márcio Roberto Viana |
| Keywords: | Toxicidade Aguda;Zingiberaceae |
| Issue Date: | 2007 |
| Publisher: | Biologia Geral e Experimental |
| Citation: | MENEZES, I. A. C. ; CARVALHO, A. A. ; ANTONIOLLI, A. R. ; SANTOS, M. R. V. Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae). Biol. Geral Exper., São Cristóvão, SE, v. 7, n. 1, p.9-13, 2007. |
| Abstract in Brazilian Portuguese: | Os efeitos cardiovasculares e a toxicidade aguda do extrato aquoso das folhas de Costus spicatus (AECS) foram estudados em ratos e camundongos. Em ratos normotensos não-anestesiados, (n = 6), AECS (0.5,1.0, 5 e 10.0 mg/kg; i.v., aleatoriamente) induziu hipotensão associado com taquicardia. Em anéis intactos ou sem endotélio da artéria mesentérica superior de rato, AECS (0.1 - 100.0 μ g/mL, n = 4) provocou relaxamento do tônus induzido por 10 μ M de fenilefrina. O extrato demonstrou baixa toxicidade aguda em camundongos |
| Abstract: | Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (AECS) were studied in rats and mice. In non anaesthetized normotensive rats (n = 6), AECS (0.5, 1.0, 5.0 and 10.0 mg/kg; i.v., randomly) induced hypotension associated with tachycardia. In intact or endothelium-denuded rings of rat superior mesenteric artery, AECS (0.1 - 100.0 μ g/ mL, n = 4) provoked relaxation of the tonus induced by 10 μ M phenylephrine. The extract showed low acute toxicity in mic |
| URI: | http://www.repositorio.ufc.br/handle/riufc/5570 |
| ISSN: | 1519-1982 Impressa 1980-9689 On line |
| Appears in Collections: | DFIFA - Artigos publicados em revista científica |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2007_art_aacarvalho2.pdf | 32,71 kB | Adobe PDF | View/Open |
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