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Tipo:	Artigo de Periódico
Título :	In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii
Autor :	Cordeiro, Rossana de Aguiar Brilhante, Raimunda Sâmia Nogueira Rocha, Marcos Fábio Gadelha Medrano, Delia Jessica Astete Monteiro, André Jalles Tavares, Juliane Lira Lima, Rita Amanda Chaves de Camargo, Zoilo Pires de Sidrim, José Júlio Costa
Palabras clave :	Antifúngicos;Antituberculosos
Fecha de publicación :	sep-2009
Editorial :	International Journal of Antimicrobial Agents
Citación :	CORDEIRO, R. A. et al. In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii. International Journal of Antimicrobial Agents, v. 34, n. 3, p. 278-280, set. 2009.
Resumen en portugués brasileño:	The aim of the present study was to evaluate the in vitro interactions of antituberculous drugs (ATDs) withantifungalsagainst Coccidioidesposadasii .Eighteendrugcombinations,formedbyanATD(isoniazid, pyrazinamideorethambutol)plusanantifungal(amphotericinB,ketoconazole,itraconazole,fluconazole, voriconazole or caspofungin), were tested using the checkerboard method. All the antimicrobial combi- nations inhibited C. posadasii strains and synergistic interactions were observed for 10 combinations. Antagonism between the tested drugs was not observed. Stronger synergistic interactions were seen in thecombinationsformedbytriazolesplusethambutolaswellasitraconazolepluspyrazinamide.Further studies in animal models are needed to confirm the usefulness of these combinations
URI :	http://www.repositorio.ufc.br/handle/riufc/5278
ISSN :	0924-8579
Aparece en las colecciones:	DMC - Artigos publicados em revistas científicas

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