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http://repositorio.ufc.br/handle/riufc/5253| Type: | Artigo de Periódico |
| Title: | Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams in strains of burkholderia pseudomallei |
| Authors: | Brilhante, Raimunda Sâmia Nogueira Valente, L. G. A. Rocha, Marcos Fábio Gadelha Bandeira, Tereza de Jesus Pinheiro Gomes Cordeiro, Rossana de Aguiar Lima, Rita Amanda Chaves de Leite, João Jaime Giffoni Ribeiro, Joyce Fonteles Castelo-Branco, Débora de Souza Collares Maia Monteiro, Andre Jalles Sidrim, José Júlio Costa Pereira, J. F. |
| Keywords: | beta-Lactamas;Burkholderia |
| Issue Date: | Apr-2012 |
| Publisher: | Antimicrobial Agents and Chemotherapy |
| Citation: | BRILHANTE, R. S. N. et al. Sesquiterpene farnesol contributes to increased susceptibility to beta-Lactams in strains of Burkholderia pseudomallei. Antimicrobial Agents and Chemotherapy, v. 56, n. 4, p. 2198-2200, abr. 2012. |
| Abstract: | This study aimed to evaluate the in vitro combination of farnesol and -lactams against Burkholderia pseudomallei . A total of 12 -lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 M. The combination of this compound with -lactams resulted in statistically significant -lactam MIC reduc- tion ( P < 0.05). This study provides new perspectives for the use of farnesol combined with -lactam antibiotics against strains of B. pseudomallei. |
| URI: | http://www.repositorio.ufc.br/handle/riufc/5253 |
| ISSN: | 0066-4804 |
| Appears in Collections: | DMC - Artigos publicados em revistas científicas |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2012_art_raclima2.pdf | 117,15 kB | Adobe PDF | View/Open |
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