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http://repositorio.ufc.br/handle/riufc/4939| Type: | Artigo de Periódico |
| Title: | Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals |
| Authors: | Medrano, Delia Jessica Astete Cordeiro, Rossana de Aguiar Marques, Francisca Jakelyne de Farias Andrade, Heuziwanne Tavares Leite Perdigão Neto, Lauro Vieira Tavares, Juliane Lira Lima, Rita Amanda Chaves de Patoilo, Kharla Kharolyni Nobre Rabelo Monteiro, Andre Jalles Brilhante, Raimunda Sâmia Nogueira Rocha, Marcos Fábio Gadelha Camargo, Zoilo Pires de Sidrim, José Júlio Costa |
| Keywords: | Antifúngicos;Suscetibilidade a Doenças |
| Issue Date: | Dec-2011 |
| Publisher: | Memórias do Instituto Oswaldo Cruz |
| Citation: | MEDRANO, D. J. A. et al. Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals. Mem. Inst. Oswaldo Cruz, Rio de Janeiro, v. 106, n. 8, p. 1045-1048, dez. 2011. |
| Abstract: | The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii. |
| URI: | http://www.repositorio.ufc.br/handle/riufc/4939 |
| ISSN: | 1045-1048 |
| Appears in Collections: | DMC - Artigos publicados em revistas científicas |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2011_art_djamedrano.pdf | 344,63 kB | Adobe PDF | View/Open |
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