Determinação Simultânea de Dopamina e Acetaminofeno sobre Eletrodo de Carbono Vítreo Modificado Nanopartículas de Ouro, Nanotubos de Carbono e Ftalocianinas de Cobalto

Abstract

I the present work was investigated an electroanalytical method for simultaneous determination of dopamine (DA) and acetaminophen (AAF) in water and Tylenol®his using modified glassy carbon electrode (GCE) was modified with gold nanoparticles (AuNp), multi-walled functionalized carbon nanotubes (FMWCNTs) and cobalt phthalocyanine (Co-Ft) jointly with square wave voltammetry technique (SWV). They were addressed in this work, the study of the electrode configuration, well with the desorption study, evaluation of the electrolyte and pH in the electrochemical response of AAF, optimization of VOQ parameters, the construction of calibration curves and application of the proposed method. The optimized conditions for the GCE/AuNp/FMWCNTs-Co-Ft electrode were: Sörensen buffer, pH 7, f = 20 s–1, a = 25 mV e ∆Es = 2 mV. Making use of these optimized conditions, analytical curves of acetaminophen were obtained in the concentration range of 7.936×10–7 to 5.213×10–6 mol L–1 (R = 0.980), LOD = 6.298×10–7 mol L–1 e LOQ = 2.099×10¬–6 mol L–1, dopamine analytical curve with a linear range of 4.975×10–7 to 6.542×10–6 mol L–1 (R = 0.998), LOD = 1.348×10–7 mol L–1, LOQ = 4.492×10–7 mol L–1, analytical curve of acetaminophen in the presence of dopamine in the concentration range of 7.936×10–7 to 8.257×10–6 mol L–1 (R = 0.999), LOD = 3.27×10–7 mol L–1,LOQ = 1.09×10–6 mol L–1, analytical curve of dopamine in the presence of acetaminophen in the analytical curve of acetaminophen in the presence of dopamine in the 4,97×10–7 to 5.66×10–6 mol L–1 (R = 0.999), LOD = 4.64×10–7 mol L¬–1, LOQ = 1.55×10–6 mol L–1 and simultaneous analytical curve with a concentration range of 1.478×10–6 to 7.834×10–6 mol L–1 (R = 0.952), LOD = 1.14×10–5 mol L–1, LOQ = 3.81×10–5 mol L–1 for the AAF and concentration range of 4.975×10¬–7 to 6.542×10–6 mol L–1 (R = 0.966), LOD = 8.45 ×10–7 mol L–1 e LOQ = 2.81×10–7 mol L–1 of the DA. The RSD values for reproducibility and repeatability were 2.83% and 3.2% for DA, respectively, 4.21% and 4.56% for AAF, respectively. The simultaneous recovery percentages were 85.18% in the water analysis for DA and 77.98% for analysis AAF in Tylenol®. The results obtained by the use of GCE/AuNp/FMWCNTs-Co-Ft proved very efficient for the simultaneous detection and recovery DA and AAF and can be considered an promising alternative tool for the simultaneous determination of these analytes.