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Type: Artigo de Periódico
Title: Suzuki-Miyaura coupling between 3-Iodolawsone and arylboronic acids. Synthesis of lapachol analogues with antineoplastic and antileishmanial activities
Authors: Gomes, Sara L. S.
Militão, Gardenia C. G.
Costa, Arinice M.
Pessoa, Cláudia Ó.
Costa-Lotufo, Letícia V.
Torres-Santos, Eduardo C.
Costa, Paulo R. R.
Silva, Alcides J. M. da
Cunha-Junior, Edézio F.
Keywords: Quinones;Quinonas;Levopropoxifeno
Issue Date: 2017
Publisher: Journal of the Brazilian Chemical Society
Citation: GOMES, S. L. S. et al. Suzuki-Miyaura coupling between 3-Iodolawsone and Arylboronic acids. Synthesis of Lapachol analogues with antineoplastic and antileishmanial activities. Journal of the Brazilian Chemical Society, São Paulo, v. 28, n. 8, p. 1573-1584, 2017.
Abstract: A series of 2-hydroxy-3-arylnaphthalene-1,4-diones (3-aryllawsones) were synthesized by Suzuki-Miyaura cross coupling reaction of 3-iodolawsone with arylboronic acids/esters. The hydroxylated resulting products were transformed into their corresponding N , N -diethyl carbamates. The antineoplastic and antileishmanial activities of the compounds were evaluated and compared with lapachol and its carbamate, providing promising results.
ISSN: 0103-5053
Appears in Collections:PPGF - Artigos publicados em revistas científica

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