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Tipo:	Artigo de Periódico
Título :	A protein isolate from Moringa oleifera leaves has hypoglycemic and antioxidant effects in Alloxan-induced diabetic mice
Autor :	Paula, Paulo C. Sousa, Daniele de Oliveira Bezerra de Oliveira, José Tadeu Abreu de Carvalho, Ana Fontenele Urano Alves, Bella Giselly Torres Pereira, Mirella L. Farias, Davi F. Viana, Martonio P. Santos, Flavia A. Morais, Talita C. Vasconcelos, Ilka M.
Palabras clave :	Moringa;Alloxan;Aloxano;Antioxidantes
Fecha de publicación :	2017
Editorial :	Molecules
Citación :	PAULA, P. C. et al . A Protein isolate from Moringa oleifera leaves has hypoglycemic and antioxidant effects in Alloxan-induced diabetic mice. Molecules, Basel, v. 22, p. 1-15, 2017.
Resumen en portugués brasileño:	Moringa oleifera has been used in traditional medicine to treat diabetes. However, few studies have been conducted to relate its antidiabetic properties to proteins. In this study, a leaf protein isolate was obtained from M. oleifera leaves, named Mo-LPI, and the hypoglycemic and antioxidant effects on alloxan-induced diabetic mice were assessed. Mo-LPI was obtained by aqueous extraction, ammonium sulphate precipitation and dialysis. The electrophoresis profile and proteolytic hydrolysis confirmed its protein nature. Mo-LPI showed hemagglutinating activity, cross-reaction with anti-insulin antibodies and precipitation after zinc addition. Single-dose intraperitoneal (i.p.) administration of Mo-LPI (500 mg/kg·bw) reduced the blood glucose level (reductions of 34.3%, 60.9% and 66.4% after 1, 3 and 5 h, respectively). The effect of Mo-LPI was also evidenced in the repeated dose test with a 56.2% reduction in the blood glucose level on the 7th day after i.p. administration. Mo-LPI did not stimulate insulin secretion in diabetic mice. Mo-LPI was also effective in reducing the oxidative stress in diabetic mice by a decrease in malondialdehyde level and increase in catalase activity. Mo-LPI (2500 mg/kg·bw) did not cause acute toxicity to mice. Mo-LPI is a promising alternative or complementary agent to treat diabetes.
URI :	http://www.repositorio.ufc.br/handle/riufc/25243
ISSN :	ISSN: 1420-3049
Aparece en las colecciones:	DMC - Artigos publicados em revistas científicas

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