Por favor, use este identificador para citar o enlazar este ítem: http://www.repositorio.ufc.br/handle/riufc/24803
Título em portugués: Depression in cancer : the many biobehavioral pathways driving tumor progression
Autor: Bortolato, Beatrice
Hyphantis, Thomas N.
Valpione, Sara
Perini, Giulia
Maes, Michael
Morris, Gerwyn
Kubera, Marta Kubera
Köhler, Cristiano A.
Fernandes, Brisa S.
Stubbs, Brendon
Pavlidis, Nicholas
Carvalho, André F.
Palabras clave : Transtorno Depressivo Maior
Depressive Disorder, Major
Fecha de publicación : ene-2017
Editorial : Cancer Treatment Reviews
Citación : BORTOLATO, Beatrice et al. Depression in cancer : the many biobehavioral pathways driving tumor progression. Cancer Treatment Reviews, v. 52, p. 58-70, jan. 2017.
Resumen en inglés: Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four- times higher than the general population. Depression confers worse outcomes, including non- adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote: (1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic–pituitaryadrenal axis. Consequently, the prompt recognition of depression among patients with cancer who may benefit of treatment strategies targeting depressive symptoms, cognitive dysfunction, fatigue and sleep disturbances, is a public health priority. Moreover, behavioral strategies aiming at reducing psychological distress and depressive symp- toms, including addressing unhealthy diet and life-style choices, as well as physical inactivity and sleep dysfunction, may represent important strategies not only to treat depression, but also to improve wider cancer-related outcomes. Herein, we provide a comprehensive review of the intertwined biobehavioral pathways linking depression to cancer progression. In addition, the clinical implications of these findings are critically reviewed.
URI : http://www.repositorio.ufc.br/handle/riufc/24803
metadata.dc.type: Artigo de Periódico
ISSN : 0305-7372
Aparece en las colecciones: DMC - Artigos publicados em revistas científicas

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
2017_art_bbortolato.pdf508,36 kBAdobe PDFVisualizar/Abrir

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.