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Type: Artigo de Periódico
Title: New terpenoids from Croton limae (Euphorbiaceae)
Authors: Sousa, Antonio H.
Silva Junior, José N.
Guedes, Maria L. S.
Braz-Filho, Raimundo
Costa-Lotufo, Letícia V.
Araújo, Ana J.
Silveira, Edilberto R.
Lima, Mary A. S.
Keywords: Diterpenos;Diterpenes
Issue Date: Aug-2015
Publisher: Journal of the Brazilian Chemical Society
Citation: SOUSA, A. H. et al. New Terpenoids from Croton limae (Euphorbiaceae). Journal of the Brazilian Chemical Society, São Paulo, v. 26, n. 8, p. 1565-1572, aug., 2015.
Abstract: An asymmetrical dimer of kaurane diterpene and monoterpene and four novel diterpenes were isolated from the roots of Croton limae, along with kaempferol-3-O-glucoside, ombuin- 3-O-rutinoside and acetyl aleuritolic acid. The cytotoxic activity of the kaurane diterpene was evaluated against colorectal adenocarcinoma (HCT-116), ovarian carcinoma (OVCAR-8) and glioma (SF-295) cell lines, exhibiting IC50 values of 7.14, 8.19 and > 10 µg mL−1, respectively.
ISSN: Print version 0103-5053
On-line version 1678-4790
Appears in Collections:PPGF - Artigos publicados em revistas científica

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