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metadata.dc.type: Artigo de Periódico
Title in Portuguese: Cytogenotoxic and oxidative status evaluation of Morinda citrifolia
Author: Moraes, Germano Pinho de
Alencar, Marcus Vinícius Oliveira Barros de
Islam, Torequl
Araújo, Lidiane da Silva
Sobral, André Luiz Pinho
Machado, Kátia da Conceição
Aguiar, Rai Pablo Sousa de
Gomes Júnior, Antonio Luiz
Corrêa, Dione
Paz, Márcia Fernanda Correia Jardim
Ferreira, Paulo Michel Pinheiro
Melo-Cavalcante, Ana Amélia de Carvalho
Ferraz, Alexandre
Grivicich, Ivana
Picada, Jaqueline Nascimento
Issue Date: 2016
Publisher: International Archives of Medicine
Keywords: Morinda
Sarcoma 180
Saccharomyces cerevisiae
Citation: MORAES, G. P. de et al. Cytogenotoxic and oxidative status evaluation of Morinda citrifolia. International Archives of Medicine, v. 9, n. 96, p. 1-13, 2016.
Abstract: Cancer is one of the most leading causes of death worldwide. Morinda citrifolia was reported to have antitumor effects. Cisplatin (CDDP), Doxorubicin (DOX) and Cyclophosphamid (CPA) are the known effective chemotherapeutics, despite of having several side effects. This study evaluated antitumoral and oxidative effects of the aqueous extract of the fruit of M. critrifolia (AEMC) (15, 30, 60 and 120 µg/mL) in comparision to CDDP (1 and 5 μg/mL), CPA (20 μg/mL), DOX (2 μg/mL) and CPA + DOX (20:2 μg/mL) in Sarcoma 180 cells and Saccharomyces cerevisiae, respectively. Cytogenetic damage and DNA fragmentation were evaluated with cytokinesis-block micronucleus assay and comet assay, respectively. In addition, S. cerevisiae strains were used in oxidative damage evaluation. AEMC induced cytogenetic damage with the increased formation of micronuclei, nuclear buds and nucleoplasmic bridges compared to the antineoplastics tested. AEMC at 120 µg/ mL induced significant (p<0.05) DNA damage in Sarcoma 180 cells similar to the CDDP, as well as oxidative damage in S. cerevisiae strain deficient in mitochondrial superoxide dismutase (Sod2∆) and cytosolic catalase (Cat1∆). The bioactive compounds present in AEMC such as gallic, caffeic, chlorogenic, ellagic acid and rutin might be responsible for AEMC’s antitumoral activity.
ISSN: 1755-7682
Appears in Collections:PPGF - Artigos publicados em revistas científica

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