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dc.contributor.authorMoraes, Germano Pinho de-
dc.contributor.authorAlencar, Marcus Vinícius Oliveira Barros de-
dc.contributor.authorIslam, Torequl-
dc.contributor.authorAraújo, Lidiane da Silva-
dc.contributor.authorSobral, André Luiz Pinho-
dc.contributor.authorMachado, Kátia da Conceição-
dc.contributor.authorAguiar, Rai Pablo Sousa de-
dc.contributor.authorGomes Júnior, Antonio Luiz-
dc.contributor.authorCorrêa, Dione-
dc.contributor.authorPaz, Márcia Fernanda Correia Jardim-
dc.contributor.authorFerreira, Paulo Michel Pinheiro-
dc.contributor.authorMelo-Cavalcante, Ana Amélia de Carvalho-
dc.contributor.authorFerraz, Alexandre-
dc.contributor.authorGrivicich, Ivana-
dc.contributor.authorPicada, Jaqueline Nascimento-
dc.identifier.citationMORAES, G. P. de et al. Cytogenotoxic and oxidative status evaluation of Morinda citrifolia. International Archives of Medicine, v. 9, n. 96, p. 1-13, 2016.pt_BR
dc.description.abstractCancer is one of the most leading causes of death worldwide. Morinda citrifolia was reported to have antitumor effects. Cisplatin (CDDP), Doxorubicin (DOX) and Cyclophosphamid (CPA) are the known effective chemotherapeutics, despite of having several side effects. This study evaluated antitumoral and oxidative effects of the aqueous extract of the fruit of M. critrifolia (AEMC) (15, 30, 60 and 120 µg/mL) in comparision to CDDP (1 and 5 μg/mL), CPA (20 μg/mL), DOX (2 μg/mL) and CPA + DOX (20:2 μg/mL) in Sarcoma 180 cells and Saccharomyces cerevisiae, respectively. Cytogenetic damage and DNA fragmentation were evaluated with cytokinesis-block micronucleus assay and comet assay, respectively. In addition, S. cerevisiae strains were used in oxidative damage evaluation. AEMC induced cytogenetic damage with the increased formation of micronuclei, nuclear buds and nucleoplasmic bridges compared to the antineoplastics tested. AEMC at 120 µg/ mL induced significant (p<0.05) DNA damage in Sarcoma 180 cells similar to the CDDP, as well as oxidative damage in S. cerevisiae strain deficient in mitochondrial superoxide dismutase (Sod2∆) and cytosolic catalase (Cat1∆). The bioactive compounds present in AEMC such as gallic, caffeic, chlorogenic, ellagic acid and rutin might be responsible for AEMC’s antitumoral activity.pt_BR
dc.publisherInternational Archives of Medicinept_BR
dc.subjectSarcoma 180pt_BR
dc.subjectSaccharomyces cerevisiaept_BR
dc.titleCytogenotoxic and oxidative status evaluation of Morinda citrifoliapt_BR
dc.typeArtigo de Periódicopt_BR
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