Sistemas micelares de F127Ò, P123Ò e suas misturas como nanocarreadores dos fármacos griseofulvina e mangiferina

Abstract

T he use of copolymers in the dissolution of poorly soluble drugs in water is being increasingly practiced, principally, due to the low toxicity of these carriers and their high ef ficiency in the dissolution process. Using copolymer surfactants, which form micelles in solution, can enhance the solubility and control the time and act in the release of hydrophobic drugs in the body. The amphiphilic triblock copolymers known E m P n E m (Pl uronic®), P123 (E 21 P 67 E 21 ) and F127 (E 98 P 67 E 98 ), where E is the ethylene oxide monomer [ - (OCH 2 CH 2 ) - ] and P, propylene oxide monomer [ - OCH 2 CH(CH 3 ) - ], and the subscripts, n and m , denote the block length, being targets of this research due to their gelling p roperties at room temperature, enabling the application subcutaneo us, and its ability to solubilis e the active lipophilic in the micellar core. Binary mixtures of Pluronics® of similar hydrophobicities, mos tly, show greater solubilis ation capacity for Plur onics® alone. Thus, i n order to enhance the solubilis ation of griseofulvin drugs, drug model used in several works, and mangiferin, active antioxidant, and promote greater bioavailability of these drugs in the body systems of mixed micelles composed of F12 7 and P123 will be the focus of this research, in order to unite their gelling properties and biocompatibility for subcutaneous administration